Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies
JD Freedman, J Hagel, EM Scott, I Psallidas… - EMBO molecular …, 2017 - embopress.org
… Finally, we assessed the ability of BiTEs to activate T‐cell cytotoxicity to SKOV3 target cells
in the presence of immunosuppressive ascites or pleural fluid following infection with EnAd‐…
in the presence of immunosuppressive ascites or pleural fluid following infection with EnAd‐…
Targeting the tumor stroma with an oncolytic adenovirus secreting a fibroblast activation protein-targeted bispecific T-cell engager
J de Sostoa, CA Fajardo, R Moreno, MD Ramos… - … of cancer, 2019 - Springer
… along with the T cell-mediated cytotoxicity of CAFs were … target cancer cells through
virus-mediated oncolysis and to re-… the genome of the oncolytic adenovirus ICO15K to express a …
virus-mediated oncolysis and to re-… the genome of the oncolytic adenovirus ICO15K to express a …
An oncolytic virus expressing a T-cell engager simultaneously targets cancer and immunosuppressive stromal cells
JD Freedman, MR Duffy, J Lei-Rossmann, A Muntzer… - Cancer research, 2018 - AACR
… oncolytic adenovirus that encodes a bispecific antibody … A, Cytotoxicity in T-cell and NHDF
cocultures was assessed … tumor biopsies with EnAd-FAP-BiTE led to tumor-associated T-cell …
cocultures was assessed … tumor biopsies with EnAd-FAP-BiTE led to tumor-associated T-cell …
[HTML][HTML] Bispecific T cell engagers and their synergistic tumor immunotherapy with oncolytic viruses
Q Huang, WQ Cai, ZW Han, MY Wang… - … Journal of Cancer …, 2021 - ncbi.nlm.nih.gov
… less cytotoxic to non-cancer cells but increase their ability to … The replication of oncolytic
adenovirus in tumor cells is strictly … T cells in liquid cancer biopsy samples without additional …
adenovirus in tumor cells is strictly … T cells in liquid cancer biopsy samples without additional …
Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies
JPW Heidbuechel, CE Engeland - Journal of hematology & oncology, 2021 - Springer
… On-target off-tumor toxicity as a safety concern of redirecting … slices derived from prostate
cancer biopsies. Following virus … an oncolytic adenovirus encoding a FAP-TAc (T cell activator…
cancer biopsies. Following virus … an oncolytic adenovirus encoding a FAP-TAc (T cell activator…
Solid tumor immunotherapy with T cell engager‐armed oncolytic viruses
EM Scott, MR Duffy, JD Freedman… - Macromolecular …, 2018 - Wiley Online Library
… toxicity at the lowest dose of 0.2 × 10 9 T cells infused, with subsequent examination of patients'
liver biopsies revealing CAIX expression … ” oncolytic adenoviruses targeting both cancer …
liver biopsies revealing CAIX expression … ” oncolytic adenoviruses targeting both cancer …
Arming oncolytic adenoviruses with bi-specific T-cell engagers to improve antitumor efficacy
CA Fajardo Calderón - 2017 - diposit.ub.edu
… a new class of antibodies that re-direct T-cells to cancer cells, … that another oncolytic adenovirus
expressing a chimeric BiTE … T-cell activation, proliferation, and cell-mediated cytotoxicity …
expressing a chimeric BiTE … T-cell activation, proliferation, and cell-mediated cytotoxicity …
Oncolytic vaccinia virus expressing a bispecific T-cell engager enhances immune responses in EpCAM positive solid tumors
M Wei, S Zuo, Z Chen, P Qian, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
… primary T cell activation and T cell-mediated cytotoxicity … Fajardo et al. engineered an
oncolytic adenovirus, ICOVIR-… the efficacy of OV-BiTE in cancer biopsies. However, the lack of a …
oncolytic adenovirus, ICOVIR-… the efficacy of OV-BiTE in cancer biopsies. However, the lack of a …
Bi-and tri-specific T cell engager-armed oncolytic viruses: next-generation cancer immunotherapy
… supported bystander cell-mediated cytotoxicity. In two distinct … Indeed, treatment of fresh
clinical biopsies, including … This FBiTE was inserted in the oncolytic adenovirus ICOVIR15K …
clinical biopsies, including … This FBiTE was inserted in the oncolytic adenovirus ICOVIR15K …
Oncolytic adenovirus in cancer immunotherapy
M Peter, F Kühnel - Cancers, 2020 - mdpi.com
… The goal of this review is to provide an introduction into the … T cells to cancer cells are
bispecific T-cell engagers (BiTEs) [… T-cell cytotoxicity against M2-TAMs in cancer patient biopsies, …
bispecific T-cell engagers (BiTEs) [… T-cell cytotoxicity against M2-TAMs in cancer patient biopsies, …